► MMS - Laboratoire Mer, Molécules, Santé

EA no. 2160
Head of Laboratory : Yves-François PONCHUS

Contact : nathalie.casse @ univ-lemans.fr

Website : laboratoire MMS

Abstract :

The MMS research teams aim to investigate the marine biodiversity and the genetic and metabolic adaptation of marine organisms in response to environmental stresses.

Characterization and functional study of mobile DNA elements in marine invertebrates. Transposable elements are short DNA sequences able to move autonomously in genomes. Members of the mariner family of transposons are simple structure elements composed of one coding sequence flanked by two inverted terminal repeats. This unique coding sequence encodes a protein responsible for transposon mobility called transposase. Currently, we have isolated more than 150 mariner sequences in several marine organisms. Some of these sequences encode active transposase the functionality of which is under investigation.

       Photos : Ad'Hoc Photographie

Genetic adaptation and stress response in marine invertebrates

Both adaptation to particular ecosystems (e.g. hydrothermal vent…) and response to anthropic stress are studied in marine invertebrates at the level of gene structure and expression.

Ecophysiology and metabolism in microalgae

Main research interests of the group deal with light, ultraviolet, and metal stress on photosynthesis (photoacclimation in phytoplankton), carbon metabolism (carboxylases, carbonic anhydrases), and polyunsaturated fatty acid metabolic pathways. Enzymatic regulation using biomolecular approaches, and characterisation and functional studies of transposons in microalgae and  marine filamentous fungi are in progress.

Lipids and lipolytic enzymes from microalgae
The team is interested in two aspects dealing with research on lipases. The first one deals with the use of commercial lipases in order to produce lipid fractions rich in docosahexaenoic acid, starting from microalgal lipids. The second one is to determine if there is any interesting lipolytic activity inside microalgae, and if so, to perform the biochemical study of these enzymes and study their regulation using gene expression.

The Laboratory :

• Permanent staff : 4 Professors, 16 Associate professors, 3 Technical staff
• Specific skills : Molecular biology, Plant physiology and biochemistry, Enzyme engineering
• Main equipment : HPLC, GC, CPG-SM, Bioreactor, Modulated fluorimeter, oximeter, liquid scintillation counter, phytotronic rooms
• Main collaborations : Museum National d’Histoire Naturelle, Paris ; Max Delbrück Center for Molecular Medicine, Berlin ; Universities of Caen (France), Tours (France), HCMV (Vietnam), Oran (Algeria), Cardiff (UK), La Rochelle (France), Bretagne Sud (France), Portsmouth (UK), Lisbonne (Portugal), National Research Institutes : Yerseke (NIOO, Netherlands), Karadag (Ukraine), INRA (Nantes)


Vice-Presidente of International Relations

Catherine PAINEAU
Head of Administration

Phone :
(33) (0)2 43 83 30 05

ri@univ-lemans.fr (ri @ univ-lemans.fr)